منابع مشابه
GLUT4 exocytosis.
GLUT4 is an insulin-regulated glucose transporter that is responsible for insulin-regulated glucose uptake into fat and muscle cells. In the absence of insulin, GLUT4 is mainly found in intracellular vesicles referred to as GLUT4 storage vesicles (GSVs). Here, we summarise evidence for the existence of these specific vesicles, how they are sequestered inside the cell and how they undergo exocyt...
متن کاملSnares for GLUT4--mechanisms directing vesicular trafficking of GLUT4.
Fusion of GLUT4 vesicles with the plasma membrane is a key terminal step in insulin-regulated glucose transport. This fusion event is mediated by SNARE proteins, syntaxin 4, SNAP23 and VAMP2, through a process regulated by accessory proteins whose roles are still unclear. Munc18c is a key regulatory protein of syntaxin, and possibly of whole-SNARE complex cycling. Rab GTPases, through interacti...
متن کاملMapping insulin/GLUT4 circuitry.
One of the most important metabolic actions of insulin is catalysing glucose uptake into skeletal muscle and adipose tissue. This is accomplished via activation of the phosphatidylinositol-3-kinase/Akt signalling pathway and subsequent translocation of GLUT4 from intracellular storage vesicles to the plasma membrane. As such, this represents an ideal system for studying the convergence of signa...
متن کاملGLUT4 ready to go
GLUT4 ready to go esicles containing the glucose transporter GLUT4 travel rapidly on a microtubule network that lies just under the plasma membrane in resting cells, according to results from Lizunov et al. (page 481). The vesicles occasionally touch the plasma membrane and, when stimulated by insulin, quickly fuse with it. GLUT4 is sequestered in vesicles in resting cells. Insulin exposure ind...
متن کاملThe antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.
The cofactor of mitochondrial dehydrogenase complexes and potent antioxidant alpha-lipoic acid has been shown to lower blood glucose in diabetic animals. alpha-Lipoic acid enhances glucose uptake and GLUT1 and GLUT4 translocation in 3T3-L1 adipocytes and L6 myotubes, mimicking insulin action. In both cell types, insulin-stimulated glucose uptake is reduced by inhibitors of p38 mitogen-activated...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2008
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2007-0282